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Further reading: Venus could have been a paradise but turned into a hellscape. Earthlings, pay attention.

What will animals look like in the future?

It’s impossible to completely predict how evolution will play out in the future, but that doesn’t mean we can’t try. Reporter Mandy Nguyen asked biologists and other experts to weigh in: What could animals look like a million years from now?

The experts took the question seriously. “I do think it’s a really useful and important exercise,” Liz Alter, professor of evolutionary biology at California State University Monterey Bay, told Nguyen. In thinking about the forces that will shape the future of life on Earth, we need to think about how humans are changing environments right now.

Further reading: The animals that may exist in a million years, imagined by biologists

What causes Alzheimer’s?

There is no cure for Alzheimer’s, a neurodegenerative disease that causes dementia, and no highly effective treatments, despite decades of research. Why? For one thing, scientists don’t have a complete understanding of what causes the disease.

For years, the prevailing theory has been that Alzheimer’s is caused by pile-ups of proteins called amyloids, which effectively create plaques in the brain. But drugs that help clear amyloids from the brain don’t seem to work very well in combating the disease.

Some scientists think Alzheimer’s researchers have been too focused on this one theory, at the expense of studying other potential causes, like viral infections.

Further reading: The new Alzheimer’s drug that could break Medicare

How is a brainless yellow goo known as “slime mold” so smart?

Slime mold is an extremely simple organism that is also extraordinarily complex.

Technically, they are single-celled organisms. But many individual slime mold cells can fuse themselves together into a huge mass, capable of, well … thinking.

Slime mold can solve mazes and seems to be able to make risk-benefit decisions. There’s even evidence that slime mold can keep track of time. They do this all without a brain or even a single brain cell. Whatever mechanism allows slime mold to solve these problems, it’s evolved in a manner different from humans. How exactly do they do this? And what can it teach us about the nature of intelligence?

Further reading: Hampshire College promoted a brainless slime mold to its faculty. And it’s working on border policy.

What’s the oldest possible age a human can reach?

Is the first human to live to 150 years old alive today? We don’t know. On average, the human lifespan has risen over the decades in most of the world, but it’s unclear if there’s a ceiling. Could a human live into their second century? The technology and medicine that could make that possible may already be in development. But if it works, there will be unsettling questions for societies to answer.

Further reading: Science reporter Ferris Jabr’s piece “How Long Can We Live?” for the New York Times Magazine inspired this episode.

Are long-haul symptoms unique to Covid-19?

Millions of people around the world have dealt with long-term symptoms of Covid-19 for weeks or months after their initial infection has cleared. Some scientists say these “long-haul” symptoms are not unique to Covid. Instead, they argue that many types of viral infections can leave people with long-term symptoms, which often can go under-recognized in medicine. The question is: What connects all of these long-haul symptoms?

“It has always been [and] is the case that patients who get sick experience high levels of symptoms like those described by long-Covid patients,” Megan Hosey, assistant professor at the Johns Hopkins Department of Physical Medicine and Rehabilitation, told Vox’s Julia Belluz. “We have just done a terrible job of acknowledging [and] treating them.”

Further reading: The nagging symptoms long-haulers experience reveal a frustrating blind spot in medicine.

Why don’t doctors know more about endometriosis?

In people with endometriosis, tissue similar to what grows inside the uterus grows elsewhere in the body. It’s a chronic condition that can be debilitatingly painful. Yet doctors don’t fully understand what causes it, and treatment options are limited.

Worse, many people with endometriosis find that doctors can be dismissive of their concerns. It can take years to get an accurate diagnosis, and research into the condition has been poorly funded.

Vox reporter Byrd Pinkerton highlighted how frustrating it can be to suffer from an often-ignored, chronic condition. “It’s just so, so, so soul-crushing to just live in this body day in and day out,” one patient told Pinkerton.

Further reading: People with endometriosis experience terrible pain. There’s finally a new treatment.

Why do we have anuses — or butts, for that matter?

This is a question we never even knew we wanted to answer — until we heard the Atlantic’s Katherine Wu explain that “the appearance of the anus was momentous in animal evolution.” Before the appearance of the anus, animals had to eat and excrete through the same hole. The anus allowed for a more efficient system, and allowed animal life on Earth to grow bigger and take on new shapes and forms.

But scientists don’t have a complete picture of the evolutionary history here; they don’t know which creature developed the anus first, and when. “It’s so hard to study something that must be millions and millions of years old and doesn’t fossilize,” Wu says.

And then there’s a whole other question: Why is the human butt so big, compared with other mammals?

Further reading: Katherine Wu’s “The Body’s Most Embarrassing Organ Is an Evolutionary Marvel,” at the Atlantic.

What the heck is ball lightning?

For millennia, people have been telling stories about mysterious spheres of light that glow, crackle, and hover eerily during thunderstorms. They’ve been spotted in homes, in rural areas, in cities, on airplanes, and even passing through windows.

They seem out of this world, but scientists believe they are very much of this world. These apparitions are called ball lightning, and they remain one of the most mysterious weather phenomena on Earth.

Ball lightning usually only lasts for a few moments, and it’s impossible to predict where and when it’ll show up. You can’t hunt ball lightning and reliably find it. Ball lightning finds you.

It’s rare, but many people have seen it. Scientists don’t know exactly where it comes from, but that hasn’t stopped them from trying to make it themselves, in their labs.

Further reading: Ball lightning is real, and very rare. This is what it’s like to experience it.

And so many more…

Those are just 11 of the mysteries we’ve explored in Unexplainable. There are so many more! They include questions like: Can we predict when tornadoes will form? Where does all the plastic go in the ocean? Why do some people think they can talk to the dead? What’s the deal with “Havana syndrome”? How will the universe end? How tall is Mount Everest? Why does the placebo effect work? Find all the episodes here.

If you have ideas for topics for future shows, send us an email at unexplainable@vox.com.

 Hugh Patrick Brown/Getty Images
He made many discoveries throughout his life, including the finding that ants communicate with each other primarily through pheromones.

Benji Jones

Was there a particular wildlife encounter that stands out to you from all of your travels?

E.O. Wilson

I believe probably the most important was when I visited a little set of islands off the coast of Australia called New Caledonia and set out to be the first entomologist to arrive there and celebrate a tremendous variety of new species.

Benji Jones

Your books have really inspired people to go out and explore the world. But I can’t imagine that there are many places in the world today that haven’t been touched by humans. What you did is almost impossible to do now.

E.O. Wilson

It’s certainly more difficult, but there’s still a lot of unclaimed territory, so to speak. There are many undiscovered and unstudied species in the world — especially in remote areas in the tropics — that await even the most elementary studies, and the results are going to continue to unfold across several generations of scientists.

Benji Jones

Why is there still a strong need for basic science and cataloging more species? It seems like there’s so much pressure to solve the problem of habitat loss and other forces that are driving down biodiversity. Should we not focus instead on stopping those forces?

E.O. Wilson

We should be doing both. A rough estimate suggests that there are upward of 10 million species on the planet, and we know only a small fraction of them. [Estimates for the number of species on Earth vary, but a widely cited figure is 8.7 million, which comes from this paper.] In most cases, we just have a few specimens in museums. It would be enormously productive and useful if we made more of an effort to identify all of the species on Earth — to find out where they are and what their status is.

The opportunities are endless. They represent the equivalent of the first explorations made by people when they came out of Europe and began to explore the rest of the world. That’s what we have before us.

Benji Jones

I love this idea that there’s so much wonder still left in the world. You can go out today and find something new that might contribute to science in a productive way.

E.O. Wilson

Yes, even if you have to travel a little farther than would have been the case a few years ago. The most important discoveries are going to be made in examining the smallest of the ants, the animals, the plants. We just need to know what is on this planet. We need to have a more complete and productive understanding of how to care for the life that we’ve inherited.

 Hugh Patrick Brown/Getty Images
Wilson discovered hundreds of species of ants throughout his career.

Benji Jones

Along those lines, why should we care about a species if we don’t even know about it? If a species that we haven’t discovered is going extinct, for example, why does it matter?

E.O. Wilson

We won’t see the magnitude of our ignorance, of our excitement, or of the useful knowledge embedded in the living environment until we set out to explore all of it. That includes large numbers of small, inconspicuous species.

Benji Jones

We need to know what we have to lose.

E.O. Wilson

Yes. We need to not carelessly let any species slip away from us. If we want to know what is on this planet and why it is a live planet — what contributes to that life and what it all means, ultimately, for human existence — we should try to save it all.

Benji Jones

If you were going to give advice to a student of biology today, to explore a type of life, a type of organism, where would you recommend starting?

E.O. Wilson

If you wish, you can take a map of the world and throw a dart. Where the dart hits, you will find animals and plants and mysteries of great magnitude.

What ants can teach us about human behavior

Benji Jones

You’ve also written a lot about the biological basis of human behavior. What has studying ants and ecology taught you about the behavior of humans?

E.O. Wilson

My early interests as a kid in the American South led me to the study of ants. And I discovered, in my hometown, the first US colony of [red imported] fire ants.

What makes ants stand out and interesting to a young scientist is that they communicate with each other using chemicals — with pheromones. My interest in chemical communication among ants led me to broader studies on the origin of social behavior more generally. This brings us to humans.

Human society can be illuminated more effectively by studying how societies are put together in the vast array of organisms, from deer to starlings to ants to bees. Each species creates societies in different ways, using different senses. From that, early on in my career at Harvard, I saw the option of doing a comparative study across many species, using different sensory modalities. I saw the opportunity of building a discipline out of this.

And so about 50 years ago, I proposed a new discipline called sociobiology. I couldn’t stay away from humans. I decided to include the peculiarities of human social behavior and how it could be illuminated — the evolution of human and social behavior — by making a comparison with societies of all kinds. That got some attention.

Benji Jones

You got a lot of flack, as Rhodes details in his book, for your work trying to understand the biological or evolutionary basis of certain human behaviors. Looking back on that now, would you have done anything differently?

E.O. Wilson

As the unfavorable attention started to fade away, I was happy that I had taken the course of study that I did.

There are not many areas of science that are sensitive to the conflict with moral reasoning. It’s a challenge — that goes way back before Darwin and the idea of evolution — that causes an outpouring from time to time due to the seeming animalization of humanity and the human condition.

I can understand why sociobiology — which included human behavior as just one more possibility in the evolution of social behavior — caused alarm. But it’s held its ground, and I think sociobiology is now well-accepted.

Benji Jones

There’s obviously a lot we still don’t know. Do you think it is important that we fully understand all the biological roots of behavior? That we fill in the remaining gaps?

E.O. Wilson

I think it’s extremely important. Human behavior, as a whole generation of poets, writers, and scientists have come to realize, is deeply rooted in instinct, and there’s a history to that instinct that occurred as humans — protohumans — evolved gradually into the full species, homo sapiens. That is history. It’s prehistory, but it’s history. And it’s enormously important because human instinctive behavior and all of its consequences and all of its possible manifestations are enormously important for our understanding of our own species, our self.

Benji Jones

Part of me is a little bit scared to know the biological basis of everything. I feel like it could be a slippery slope. So, for example, I’m gay. If you could figure out the biological basis of homosexuality, that could come with some serious and perhaps unpredictable consequences. Are there any concerns that you have about knowing too much?

E.O. Wilson

No. It’s only by completely open and honest research done to the best of our ability that we can understand where we fit as a species that has evolved in the midst of a living world that has peculiar properties that have deeply influenced what we’ve become.

Wildlife conservation “has many victories in a losing war”

Benji Jones

I can’t help but think that decades of efforts to save nature haven’t accomplished much. Do you think conservation has worked?

E.O. Wilson

We have had many successes — a rainforest here, the protection of a savanna or tropical grassland there, and so on. But the sum of it all is inadequate. We don’t have a generally recognized, universally accepted moonshot effort to combine all the activity directed toward conservation into a unified, fundamentally accepted ethic of conservation. We have many victories in a losing war.

Benji Jones

Would it be fair to say that this kind of universal ethic is in line with the Half-Earth Project — your work to conserve half of the planet, both land and sea?

E.O. Wilson

In the 1960s, a young professor at Princeton, Robert MacArthur, and I decided to create a theory together on something related to our work — research on biodiversity and on what determines the number of species in a particular part of the world. We created the Theory of Island Biogeography.

It began when I put together data for ants all through the Pacific region, island by island. I saw that there was a relationship between the area of the island and the number of species found there — in this case, of ants. It turns out it applies to pretty much any organism.

 Courtesy of Jay Vavra
E.O. Wilson in Gorongosa National Park, one of the many locations where he did field work.

A relatively small increase in the area of an island resulted in a different number of species. If you can set aside 15 percent more area when building a nature reserve, you can increase the number of species that can live there, stably, by about 85 percent.

This suggested to me — just this one phenomenon — that we ought to translate that into a policy. I suggested that idea in a book entitled Half- Earth. If you can somehow make half of the Earth a reserve, you could save the vast majority of species on it.

Benji Jones

There’s been a lot of criticism of approaches that aim to increase the size of protected areas. In the past, some of those efforts removed Indigenous people from their land. Can we both add more reserves and protect the rights of Indigenous people?

E.O. Wilson

Yes. Generally, we have enough examples now from around the world to show that reserves can be created or enlarged in a safe and thoughtful manner with due consideration given to people living there — who own the property and have the methods and philosophies of conservation of their own. We can accomplish both.

Benji Jones

What advice do you have for scientists or biologists that are just starting their careers today?

E.O. Wilson

If you have even a glimmering of interest in entering the field of biology, it’s a career that, at this point in our history, is potentially enormously useful. We know that reserves are very fragile and that we need to have a science and technology of reserve creation. We need to know what is in the reserves, down to the smallest invertebrate, animal, alga, fungus, and so on — down to the last species. I would hope every student with any interest in biology at all carefully considers this type of career.

Benji Jones

How about for people who are not scientists and are just trying to live in a way that doesn’t harm the planet? What do you tell people about their own responsibility?

E.O. Wilson

Don’t cut down a boreal forest or the Amazon and have a general sense of responsibility for the remaining natural areas of the world. That doesn’t require a PhD in biodiversity. It requires a sense of personal responsibility and merit to save parts of the world that are very valuable for our history, for our welfare, and — unfortunately — are very vulnerable to careless destruction.

Benji Jones

What does that actually look like for someone in their day-to-day? What is the behavior that we should be living by?

E.O. Wilson

I’ve found that, in different parts of our country and in foreign countries, when people become familiar with what’s in their natural environment, what’s interesting, what’s important on a broader scale, what gives them pleasures, that depth of understanding leads to a long-term improvement in their quality of life.

Correction, December 3, 11 am: Due to a transcription error, a previous version of this article misstated when E.O. Wilson proposed the new discipline of sociobiology. It was 50 years ago.

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